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What this book knows
Alpha-2-HS-glycoprotein and hemopexin are serum factors that enable small-molecule WN1316 to protect neurons from oxidative injury.
mind-and-cognition
Two N-linked glycoproteins, AHSG and hemopexin, markedly exhibited WN1316-mediated cytoprotection against oxidative injury in differentiated neuroblastoma SH-SY5Y cells.
PSMF-RC-003WN1316-mediated cytoprotective activity was observed in a FBS dose-dependent manner, but not in serum-free conditions.
PSMF-RC-008AHSG binds to lipids and is internalized via endocytosis; endocytosis may be the mechanism involving WN1316 uptake into cells.
PSMF-RC-016Sugar chains conjugated on WN1316-activating factors are not necessary for the WN1316-mediated anti-oxidative stress function in vitro.
PSMF-RC-012Future studies will uncover the relationship between chemical structural features of the small molecule compound and AHSG/HPX-mediated activity.
PSMF-RC-017Illuminates
5 published passages · book excerpt · research analysis
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